We stayed at the Fairmont as part of a wedding party otherwise we probably wouldn't have picked it. Try and get a room high up - preferably in a corner - we were in 614 and had three huge windows with the most incredible views south over the city. We didn't draw the curtains at night so we could wake up and see the view.
Everyone else talks about service and the lobby so I'll keep my review to this - don't stay here if you can't manage walking up hills. The Fairmont website claims to be close to the BART station, which isn't exactly a lie, but the map doesn't show hills. The Fairmont is at the top of one. A steep one.
Luckily, we braved the streets and traffic and drove our bags to the hotel before dropping the car off at the airport after having been to Napa. Frankly we wouldn't have made the hills, up or down, with our luggage. Even without heavy bags, the hills do put you off coming and going more than once a day, unless you are either driving or are prepared to pay for taxis everywhere.
If nothing else, to say you stayed at the Fairmont San Francisco is a real buzz so you forgive the hills and the fraying decor (as did John McCain who stayed there 2 days before us), and you're guaranteed to always find you hotel in SF/USA guide books - it's a city landmark.














